Analytical Science – Reynolds Science

Feb 6th 2026

A comparison of select smokeless tobacco and tobacco-free nicotine pouches utilizing validated methods for nicotine dissolution using the dissolution apparatus 1 and dissolution apparatus 4.

This study presents the results of a method validation for nicotine dissolution using the United States Pharmacopeia (USP) basket apparatus (Apparatus 1). Furthermore, dissolution profiles of select oral tobacco products (OTP) and tobacco-free nicotine pouches (TFNP) were generated and compared with a validated method using the USP flow-through cell apparatus (Apparatus 4). Nicotine quantification at each fraction collection time from each apparatus was achieved using a single method of analysis. This study provides robust data for the validation of nicotine dissolution using Apparatus 1 (App1). Additionally, justification is provided for using App1 or Apparatus 4 (App4) when determining the nicotine dissolution profiles for any of the products included in this study. Lastly, nicotine release profiles generated from both apparatuses are compared using the difference factor (f1) and similarity factor (f2) according to the United States Food and Drug Administration (FDA) Guidance for Industry: Dissolution testing of immediate release solid oral dose forms (FDA CDER, 1997).

Sep 2nd 2024

Evaluation of environmental emissions from glo heated tobacco products and combustible cigarettes

Environmental Advances, 2024

Jun 12th 2023

Identification and Quantitation of Nicotine Polacrilex in Nicotine Pouches and Other Oral Nicotine Delivery Products

Contributions to Tobacco & Nicotine Research, 2023

Apr 27th 2022

Does the Level of NNK in Tobacco and Tobacco Products Depend on the Level of Pseudooxynicotine or of Nicotine-1′-N-Oxide?

Contributions to Tobacco & Nicotine Research, 2022

Dec 25th 2021

A Single-Center Evaluation of Environmental Emissions from Electronic Cigarettes and Combustible Cigarettes

Contributions to Tobacco & Nicotine Research, 2021

Jul 16th 2021

Machine Vaping of Electronic Cigarettes – A Comparison of Puffing Regimes

Several machine-based puffing regimes for collection of e-cigarette aerosol were evaluated with the objective of recommending one regime for standardization. The study involved a comparison of several candidate regimes for which puff volume, duration, interval, profile shape, and puff number were defined and varied.

Nov 15th 2019

Development of a quantitative method for assessment of dose in in vitro evaluations using a VITROCELL® VC10® smoke exposure system

The aims of this study were to investigate dosimetry during whole smoke exposure in the VITROCELL® VC10® smoking robot using quartz crystal microbalances (QCMs) and to support the use of photometers for concurrent assessment of ‘dose’ during whole smoke exposures. QCM results showed consistent deposition across different exposure chambers, between dilution bars, experiments and modules.

Feb 28th 2017

Analysis of Traces of Tobacco-Specific Nitrosamines (TSNAs) in USP Grade Nicotine, E-Liquids, and Particulate Phase Generated by the Electronic Smoking Devices

The present study describes the development of a liquid chromatography tandem mass spectrometry (LC-MS/MS) technique for the analysis of trace levels of four tobaccospecific nitrosamines (TSNAs): nitrosoanabasine (NAB), nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and nitrosonornicotine (NNN).

Jan 30th 2015

Particle Size Distribution of E-Cigarette Aerosols and the Relationship to Cambridge Filter Pad Collection Efficiency

Described here is a study in which e-cigarette aerosols were collected on Cambridge filters with adsorbent traps placed downstream in an effort to capture any material passing through the filter.