Tobacco Science Conferences
Built Around Engaging Scientists,
Regulators, and Policymakers

The 61st Society of Toxicology meeting included 2,000+ scientific presentations across 70+ sessions; 250 exhibitors with products and services in the ToxExpo; and scores of networking and social events with over 6,000 attendees.

As the premier conference for the food and drug law community, the FDLI Annual Conference addresses complex legal, regulatory, compliance, and policy issues in all facets of the FDA-regulated industry. The conference provides in-depth discussions and analyses on a wide variety of timely topics by bringing together experts from the federal government, industry, the private bar, non-profit, patient and consumer advocates, consulting organizations, and academia.

Next Generation Nicotine Delivery brought together business leaders from the ENDS and tobacco industry across the US market along with solution providers for 2 days of valuable insights, discussions, and debates into how manufacturers can:

• Address generational differences and shifts in taste as the health and wellness agenda intensifies
• Anticipate growth in new product categories, including tobacco and nicotine
• Increase user experience by providing stimulation and pleasure
• Review recent product innovation and portfolio development to identify opportunities for growth
• Offset the predicted decline of cigarette consumption
• Appeal to the new consumer by creating alternative formats from buccal to inhalation

The 62nd Society of Toxicology meeting was held in Nashville, TN from March 19^th-23^rd. It included more than 70 featured and scientific sessions alongside 2,000+ poster presentations and a three-day ToxExpo featuring 250 companies. Reynolds was represented by several scientists who presented 7 posters during the Tobacco and ENDS Toxicology sessions.

The posters and lead authors are below:

“Assessment of the Cell Transformation Assay Using Traditional and Next-Generation Tobacco Products”, Reagan McRae

“Cytotoxicity Assessment of Heated Tobacco Product and Combustible Cigarette Aerosols Utilizing Whole Aerosol Exposure in the Neutral Red Uptake Assay”, Robert Leverette

“Development of Organotypic Air-Liquid Interface Cultures as Models for Smoking-Related Lung Disease Endpoints”, Patrudu Makena

“Genotoxicity Assessment of Combustible Cigarette, Heated Tobacco Product (HTP), and Electronic Nicotine Delivery Systems (ENDS) Aerosols and Modern Oral (MO) Nicotine Product Extracts in the Ames and In Vitro Micronucleus Assays”, Robert Leverette

“Genotoxicity Assessment of Heated Tobacco Product and Combustible Cigarette Aerosols in the Ames and In Vitro Micronucleus Assays”, Ken Szeliga

“In Vitro Cytotoxicity Assessment of Whole Aerosol/Smoke Generated from Heated Tobacco Products and Combustible Cigarettes in the EpiAirway Tissue Model”, John Wertman

“Nrf2 Responses in a 3D Human Airway Model Exposed to Whole Aerosol from Combustible Cigarettes or Heated Tobacco Products”, Brian Keyser

The Tobacco and Nicotine Product Regulatory Science Symposium will provide a forum for diverse stakeholders to share scientific studies and research from a wide range of disciplines. Presentations will focus on studies and research that are either conducted for or contribute to the U.S. regulatory process, which is established by the Tobacco Control Act and administered by the U.S. Food and Drug Administration’s Center for Tobacco Products (CTP). These presentations will be critiqued and discussed by expert panelists, and event attendees will also have the opportunity to engage in constructive dialogue with both presenters and panelists.

Chris Junker, Vice President, Life Science Capabilities, Vapor and W&S Submissions, will present “Measuring the Impact of Menthol and Tobacco-Flavored Vapor Product Use on Cigarette Smoking Cessation and Reductions: The Longitudinal Tobacco Use and Transitions Survey (LTTS)”.

The College on Problems of Drug Dependence (CPDD) Annual Scientific Meeting served as a forum bringing together basic scientists and clinical investigators from industry, academia, and government. Representatives of regulatory agencies, as well as scientists and professionals in several diverse disciplines interested in the biochemical, behavioral, and public health aspects of drug dependence participated.

Tiffany Parms, Master Scientist, Clinical Studies, presented “Actual Use Study of Nicotine Pouches Among U.S. Adult Smokers”.

Sky Carmen, Master Scientist Vapor Submissions, presented “Navigating the FDA PMTA Landscape from a Device Engineering Perspective for Next Generation Product Submissions”.